There were 240 newly advanced schistosomiasis patients in Huangshan City from 2004 to 2011. All the patients were clinically diagnosed and mainly distributed in the countries which were once heavy endemic areas in history. Most of the patients were diagnosed in 2007 and 2008, and those aged more than 60 years accounted for 79.16% of the total cases. Among all the cases, ascites type and splenomegaly type accounted for 66.25% and 31.66% respectively. In conclusion, there are still newly advanced schistosomiasis cases in areas of schistosomiasis transmission interruption, so the monitoring, diagnosis and treatment of historical schistosomiasis patients should be strengthened.