Expression of acetylcholinesterase in sub regions of brain in different aged rat with chronic unpredictable mild stress

Objective To observe the effects CUMS on the activity of Acetylcholinesterase (AchE) in sub regions of brain in different aged rat. Methods Immunohistochemistry was applied to investigate the activity of AchE in prefrontal, hippocampus, striatum and inferior calculus of old ,middle and young rats on chronic unpredictable mild stress from 21 days. Results There was greater change in the AchE expression than in the control group(P0.05). Conclusions CUMS can induce significant increase of AchE expression in sub regions of brain in different aged rat.