炔烃
电石
化学
咪唑
乙炔
组合化学
联轴节(管道)
碳化物
有机化学
催化作用
冶金
材料科学
作者
Lang Liü,Guangmin Sun,Jun Zhang
标识
DOI:10.1002/adsc.202300221
摘要
Abstract Imidazole derivatives are critical building blocks in the synthesis of pharmaceuticals, fluorescent materials, and ligands. Despite the development of many strategies, the reliable synthesis of 2,4,5‐substituted imidazoles remains heavily researched. In this study, we present a protocol for synthesizing 2,4,5‐substituted imidazole‐bearing methyl groups using A3‐coupling cyclization with calcium carbide as the acetylene source, reacting with amidines and aldehydes. This methodology is characterized by several features, including the utilization of a solid alkyne source, readily accessible starting materials, and applicability to 34 examples.
科研通智能强力驱动
Strongly Powered by AbleSci AI