医学
功能性二尖瓣反流
心脏病学
射血分数
射血分数保留的心力衰竭
内科学
二尖瓣反流
背景(考古学)
心室
心力衰竭
舒张期
反流(循环)
血压
古生物学
生物
作者
Mauro Riccardi,Maja Čikeš,Marianna Adamo,Matteo Pagnesi,Claudio Lombardi,Scott D. Solomon,Marco Metra,Riccardo M. Inciardi
标识
DOI:10.1016/j.cardfail.2024.02.024
摘要
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and associated with worse cardiovascular outcomes. The pathophysiology of HFpEF mostly relies on the development of elevated left ventricle filling pressure, diastolic dysfunction, and atrial dilatation and impairment. This dynamic process may eventually lead to the development of functional mitral regurgitation (MR), characterized by mitral annular dilatation and consequent leaflet remodeling, in the context of preserved left ventricular ejection fraction. These observations highlight the possible common pathophysiology of MR and HFpEF. However, less is known about the prevalence and the clinical value of MR in the context of HFpEF. This review aims to provide an overview of the association and interplay between functional MR and HFpEF, discuss the underlying mechanisms that are common to these diseases, and summarize potential targeted pharmacological treatments.
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