生物相容性
化学
光热治疗
抗菌剂
自愈水凝胶
灭菌(经济)
金黄色葡萄球菌
肿胀 的
抗菌活性
伤口愈合
化学工程
纳米技术
细菌
材料科学
高分子化学
有机化学
外科
医学
工程类
生物
货币经济学
经济
外汇市场
遗传学
外汇
作者
Yuwei Hu,Qin Zeng,Yifan Hu,Jing He,Heye Wang,Chao Deng,Dai Li
出处
期刊:Talanta
[Elsevier]
日期:2024-01-01
卷期号:266: 125101-125101
标识
DOI:10.1016/j.talanta.2023.125101
摘要
Bacterial infections can significantly impair wound healing. Therefore, it is essential to develop wound dressings with high antimicrobial activity. Hydrogels are often used as wound dressings due to their excellent physicochemical properties. Herein, by cross linking sodium alginate (SA), agar (AG) with Ti3C2Tx MXene and Zinc ions (Zn2+), a biosafe composite hydrogel (MSG-Zn2+) was developed for fast and efficient sterilization treatment. The excellent photothermal properties of Ti3C2Tx MXene and the chemical antimicrobial activity of Zn2+ enable synergistic photothermal therapy (PTT)/chemical therapy in NIR biowindow with reduced power density and improved antimicrobial efficiency. More importantly, the incorporation of Zn2+ can enhance the effective contact between the hydrogel and bacteria, benefiting both photothermal and chemical antibacteria. In vitro antibacterial experiments showed that MSG-Zn2+ has a broad-spectrum antibacterial effect against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). Cellular experiments showed that the hydrogel had excellent biocompatibility and the released Zn2+ stimulated cell migration. In addition, the prepared MSG-Zn2+ hydrogel has other advantages such as hydrophilic, high swelling, simple and low cost preparation, which meets the requirements of an economical wound dressing. This proposed work shows that this composite hydrogel MSG-Zn2+ has great potential for practical antimicrobial wound dressing applications.
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