化学
高价分子
酚类
试剂
电化学
分子内力
乙醚
化学计量学
有机化学
催化作用
惰性
芳基
苯酚
碘
惰性气体
组合化学
电极
烷基
物理化学
作者
Somayyeh Sarvi Beigbaghlou,Robert S. Yafele,Marcin Kalek
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2023-07-13
卷期号:55 (24): 4173-4180
被引量:1
摘要
Abstract An electrochemical oxidative ortho-dearomatization of naphthols and phenols with an intramolecular C–O bond formation has been developed. A careful optimization of the reaction parameters allowed for the application of free phenols as the starting materials, in contrast to the existing alternative procedures necessitating aryl methyl ether substrates. The reaction delivers an array of spirolactones and spiroethers in yields up to 97%, under simple experimental conditions: in a constant current mode, using an undivided cell, and without an inert atmosphere. The method avoids using catalysts or stoichiometric oxidants (e.g., hypervalent iodine reagents), generating hydrogen as the sole byproduct.
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