The topography of the Puyang River catchment is complex and includes hills and plains. The Zhuji basin in the middle reaches a densely populated area facing serious flooding issues, due to the upstream flooding and downstream backwater. To address the problem, this study applies the Xin’anjiang hydrological model and IFMS 1D-2D hydrodynamic model, to simulate flood scenarios. The simulation results demonstrated that the hydrological model and the -hydrodynamic model together are a feasible tool to monitor the flooding process in the Puyang River catchment. In addition, different flood scenarios which consider disaster-inducing factors and flood control operations are simulated by the model. Reasonable solutions are analyzed for the local flood management.