紫杉醇
医学
乳腺癌
转移性乳腺癌
药效学
癌症
药代动力学
药理学
临床试验
耐火材料（行星科学）
肿瘤科
内科学
癌症研究
生物
天体生物学
作者
Cristiano Ferrario,John R. Mackey,Karen A. Gelmon,Nathalie LeVasseur,Poul H. Sorensen,Htoo Zarni Oo,Gian Luca Negri,Victor Tse,Sandra E. Spencer Miko,Grace Cheng,Gregg B. Morin,Sonia V. del Rincón,Tiziana Cotechini,Christophe Gonçalves,Charles C.T. Hindmarch,Wilson H. Miller,Mehdi Amiri,Tayebeh Basiri,Victor Villareal-Corpuz,Sam Sperry
标识
DOI：10.1158/1078-0432.ccr-24-0841
摘要
We conclude that tomivosertib effectively inhibits MNK1/2 activity in metastatic breast cancer tissue and that it can safely be combined with paclitaxel in future phase II studies. We demonstrate feasibility of using proteomic profiles, translatomic profiles, and spatial distribution of immune cell infiltrates for clinical pharmacodynamic studies.
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(2025-6-4)
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