Pan-Genome Analysis and Secondary Metabolic Pathway Mining of Biocontrol Bacterium Brevibacillus brevis

生物 细菌 生物病虫害防治 微生物学 基因组 遗传学 生态学 基因
作者
Jie Du,Binbin Huang,Jun Huang,Qingshan Long,Cuiyang Zhang,Zhaohui Guo,Yunsheng Wang,Wu Chen,Shiyong Tan,Qingshu Liu
出处
期刊:Agronomy [Multidisciplinary Digital Publishing Institute]
卷期号:14 (5): 1024-1024
标识
DOI:10.3390/agronomy14051024
摘要

Brevibacillus brevis is one of the most common biocontrol strains with broad applications in the prevention and control of plant diseases and insect pests. In order to deepen our understanding of B. brevis genomes, describe their characteristics comprehensively, and mine secondary metabolites, we retrieved the genomic sequences of nine B. brevis strains that had been assembled into complete genomes from the NCBI database. These genomic sequences were analyzed using phylogenetic analysis software, pan-genome analysis software, and secondary metabolite mining software. Results revealed that the genome size of B. brevis strains ranged from 6.16 to 6.73 Mb, with GC content ranging from 47.0% to 54.0%. Phylogenetic analysis classified the nine B. brevis strains into three branches. The analyses of ANI and dDDH showed that B. brevis NEB573 had the potential to become a new species of Brevibacillus and needed further research in the future. The pan-genome analysis identified 10032 gene families, including 3257 core gene families, 3112 accessory gene families, and 3663 unique gene families. In addition, 123 secondary metabolite biosynthetic gene clusters of 20 classes were identified in the genomes of nine B. brevis strains. The major types of biosynthetic gene clusters were non-ribosomal peptide synthase (NRPS) and transAT polyketide synthase (transAT-PKS). Furthermore, a large number of untapped secondary metabolites were identified in B. brevis. In summary, this study elucidated the pan-genome characteristics of the biocontrol bacterium B. brevis and identified its secondary metabolites, providing valuable insights for its further development and utilization.
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