A holistic view of the malignant organism we call glioblastoma

Tumors are not simply a chaotic mass of mutated cells but can follow complex organizational principles, including in space. In this issue of Cell, Mathur and colleagues reconstruct a 3D genomic, epigenomic, and transcriptomic spatial cartograph of glioblastoma, offering a “whole-tumor” perspective with patterns of clonal expansion that are embedded in neurodevelopmental hierarchy. Tumors are not simply a chaotic mass of mutated cells but can follow complex organizational principles, including in space. In this issue of Cell, Mathur and colleagues reconstruct a 3D genomic, epigenomic, and transcriptomic spatial cartograph of glioblastoma, offering a “whole-tumor” perspective with patterns of clonal expansion that are embedded in neurodevelopmental hierarchy. Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspectiveMathur et al.CellJanuary 18, 2024In BriefAn integrative 3D spatial analysis provides a whole-tumor perspective on human glioblastoma, mapping out regional specificity in tumor and microenvironment programs while highlighting tumor-wide features as promising targets for future therapeutic development. Full-Text PDF