Preparation of new Flubendazole Microparticules using Sodium alginate, Caroboxymethyl strach and Ascorbic acid for the Colonic delivery

Diseases related to intestinal parasites require repeated administration of antihelminthic drugs throughout one's lifetime, using various routes, including oral administration. This mode of administration can pose a problem with treatment adherence for the patient. In order to overcome these difficulties, we have considered the development of new matrices: modified starch, which could facilitate the development of an oral therapeutic system (microparticules) with controlled colonic release. As the active ingredient, we used flubendazole (100 mg) in different prepared excipients: modified starch and sodium alginate, combined with other active substances; ascorbic acid and phloroglucinol as adjuvants to enhance the efficacy of flubendazole. These formulations were prepared in the form of microparticules. The study of flubendazole release in buffer solutions at pH 1.2 and pH 6.8 showed continuous release profiles. Chemically modified starch matrices using sodium monochloroacetate are suitable for the development of a controlled release system for antihelminthic drugs. The results confirm the colonic release, with an excellent enhancement when using ascorbic acid.