医学
间质细胞
胰腺炎
炎症
癌变
内科学
胰腺癌
疾病
胰腺疾病
胰腺
病理
癌症
癌症研究
免疫学
作者
Xufeng Tao,Hong Xiang,Yue Pan,Dong Shang,Junchao Guo,Ge Gao,Gary Guishan Xiao
标识
DOI:10.1016/j.phrs.2021.105595
摘要
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant lethal disease due to its asymptomatic at its early lesion of the disease and drug resistance. Target therapy associated with molecular pathways so far seems not to produce reasonable outcomes. Understanding of the molecular mechanisms underlying inflammation-initiated tumorigenesis may be helpful for development of an effective therapy of the disease. A line of studies showed that pancreatic tumorigenesis was resulted from pancreatitis, which was caused synergistically by various pancreatic cells. This review focuses on those players and their possible clinic implications, such as exocrine acinar cells, ductal cells, and various stromal cells, including pancreatic stellate cells (PSCs), macrophages, lymphocytes, neutrophils, mast cells, adipocytes and endothelial cells, working together with each other in an inflammation-mediated microenvironment governed by a myriad of cellular signaling networks towards PDAC.
科研通智能强力驱动
Strongly Powered by AbleSci AI