伤口愈合
神经生长因子
神经营养因子
受体
神经营养素
医学
原肌球蛋白受体激酶A
免疫学
内科学
作者
Zhenxing Li,Haiwei Wu,Shengyun Huang
出处
期刊:Experimental and Therapeutic Medicine
[Spandidos Publications]
日期:2021-04-11
卷期号:21 (6)
被引量:28
标识
DOI:10.3892/etm.2021.10031
摘要
Wound healing is an important and complicated process that includes four highly integrated and overlapping phases, haemostasis, inflammation, proliferation and tissue remodelling. Nerve growth factor (NGF) was the first member of a family of neurotrophic factors to be discovered, and is an essential neurotrophic factor for the development and maintenance of the central and peripheral nervous systems. Several studies have proposed that NGF and its receptors, tropomyosin-related kinase receptor 1 and NGF receptor, are involved in the wound healing process, and are important components of the healing of several wounds both in vivo and in vitro. Topical application of NGF significantly promotes the healing of different types of wounds, including diabetic foot ulcers, pressure ulcers and corneal wounds. The present review summarizes the status of NGF and its receptors in current literature, and discusses data obtained in the last few years on the healing action of NGF in cutaneous, corneal and oral wounds.
科研通智能强力驱动
Strongly Powered by AbleSci AI