Variant PNLDC1 , Defective piRNA Processing, and Azoospermia
无精子症
遗传学
生物
计算机科学
不育
怀孕
作者
Liina Nagirnaja,Nina Mørup,John Nielsen,Rytis Stakaitis,Ieva Golubickaitė,Manon S. Oud,Sofia Boeg Winge,Filipa Carvalho,Kenneth I. Aston,Francesca Khani,Godfried W. van der Heijden,C. Joana Marques,Niels E. Skakkebæk,Ewa Rajpert‐De Meyts,Peter N. Schlegel,Niklas Rye Jørgensen,Joris A. Veltman,Alexandra M. Lopes,Donald F. Conrad,Kristian Almstrup
Our results suggest a direct mechanistic effect of faulty piRNA processing on meiosis and spermatogenesis in men, ultimately leading to male infertility. (Funded by Innovation Fund Denmark and others.).