部分
化学
取代基
吡啶
酚类
重氮
抗菌剂
组合化学
苯酚
戒指(化学)
有机化学
作者
Tehreem Tahir,Muhammad Ashfaq,Muhammad Saleem,Muhammad Rafiq,Mirza Imran Shahzad,Mariusz Mojzych,Mariusz Mojzych
出处
期刊:Molecules
[MDPI AG]
日期:2021-08-11
卷期号:26 (16): 4872-4872
被引量:18
标识
DOI:10.3390/molecules26164872
摘要
Synthetic heterocyclic compounds have incredible potential against different diseases; pyridines, phenolic compounds and the derivatives of azo moiety have shown excellent antimicrobial, antiviral, antidiabetic, anti-melanogenic, anti-ulcer, anticancer, anti-mycobacterial, anti-inflammatory, DNA binding and chemosensing activities. In the present review, the above-mentioned activities of the nitrogen-containing heterocyclic compounds (pyridines), hydroxyl (phenols) and azo derivatives are discussed with reference to the minimum inhibitory concentration and structure–activity relationship, which clearly indicate that the presence of nitrogen in the phenyl ring; in addition, the hydroxyl substituent and the incorporation of a diazo group is crucial for the improved efficacies of the compounds in probing different diseases. The comparison was made with the reported drugs and new synthetic derivatives that showed recent therapeutic perspectives made in the last five years.
科研通智能强力驱动
Strongly Powered by AbleSci AI