Objective To analyze the variety and clinic signification of lipids in patients with subclinical hypothyr oidism. Methods The levels of TSH,FT3,FT4,TC,TG,LDL-C,HDL-C in 52 subclinical hypothyroidism patients,60 controls and 55clinical hypothyroidism patients were determined and compared. Results Compared with the control the levels of LDL-C,TSH in clinical hypothyroidism and subclinical hypothyroidism patiens were higher (P0.01); the levels of FT4,TC, TG in clinical hypothyroidism patients were higher (P0.01). The level of TC in subclinical hypothyroidism patiens and FT3 in clinical hypothyroidism patients was higher (P0.05). Compared with subclinical hypothyroidism,the levels of FT4,TC, TG,TSH、FT3 in clinical hypothyroidism patiens was higher (P 0.01 or P 0.05). Conclusion The level of lipids in subclinical hypothyroidism patients is abnormal and it amy be close to clinical hypothyroidism.