Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure

Metabolic alterations are a hallmark of heart failure and differ across stages. The immune system plays a critical role in cardiac repair and injury during heart failure progression. Metabolic interactions between immune cells and cardiomyocytes are critical for influencing cellular states and cell-cell communications. Understanding these molecular intersections is essential to developing targeted therapies that regulate immunometabolism in the heart. In this review, we provide a comprehensive overview of the metabolic links between immune cells and cardiomyocytes during heart failure and discuss potential treatment strategies.