Sucralose is accumulated in adipose tissue and plasma but minimally impacts inflammation in lean and obese mice

, sucralose exposure did not consistently modulate basal or TNFα-induced expression of key inflammatory genes (Il6, Tnf, and Mcp1) in 3T3-L1 adipocytes or RAW 264.7 macrophages. Although adipose sucralose accumulation did not trigger inflammation and even slightly reduced inflammatory gene expression in HFD mice, its long-term metabolic consequences remain unknown. Given that adipose tissue plays a central role in cardiometabolic regulation, the potential bioaccumulation of sucralose warrants a precautionary approach and calls for further research to investigate potential effects on adipose function and broader metabolic responses.