Akkermansia muciniphila ameliorates acute liver injury aggravated by MASLD-associated dysbiosis via daidzein/PPAR-α/NF-κB signaling

MASLD-associated gut dysbiosis disrupts daidzein/PPAR-α/NF-κB signaling via gut–liver axis, heightening ALI risk. Gut dysbiosis may be a predictor for ALI in MASLD patients, and microecological or dietary interventions are preventive strategies.