硬骨素
骨形成
内分泌学
内科学
化学
成骨细胞
骨重建
骨形态发生蛋白
封锁
Wnt信号通路
抑制性突触后电位
骨愈合
骨量
细胞生物学
受体
抗体
医学
作者
Luyao Wang,Xiaohui Tao,Hewen Jiang,Shijian Ding,Ning Zhang,Xin Yang,Shenghang Wang,Yihao Zhang,Nanxi Li,Haitian Li,Zhanghao Li,Xiaoxin Wen,Meiheng Sun,Chuanxin Zhong,Heiwa So,Jin Liu,Yuanyuan Yu,Hua Yue,Xianghang Luo,Péter Ferdinandy
标识
DOI：10.1038/s41413-026-00511-x
摘要
mice. Taken together, osteoblastic sclerostin loop3-LRP4 interaction, as an anchor, was required by sclerostin to bind to LRP6, thereby inhibiting bone formation. Translationally, blockade of sclerostin loop3-LRP4 interaction in osteoblasts would provide precise therapeutic strategies to promote bone formation without increasing cardiovascular risk.
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(2025-6-4)
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