Comparative evaluation of autologous platelet-rich fibrin versus platelet-rich fibrin combined with demineralized freeze-dried bone allograft in the treatment of periodontal intrabony defects: A clinical & radiographic study

Aim: Demineralized freeze-dried bone allografts (DFDBA) are osteoinductive and platelet-rich fibrin (PRF) plays an essential role in wound repair. It also provides a matrix for migration of tissue-forming cells. Both entities may accelerate the bone healing process and soft tissues. The present study was aimed to compare the clinical and radiographic outcomes obtained with the combination of PRF and DFDBA to those obtained with PRF alone in the treatment of periodontal intrabony defects 9 months after surgical intervention. Materials and Methods: A split-mouth study was conducted in 20 subjects (40 sites - intrabony defect bilaterally). The sites had been randomly divided into two groups (Site A and Site B) in which one quadrant (Site A) received DFDBA+PRF whereas the other quadrant (Site B) received PRF alone. Clinical parameters gingival index (GI), probing depth (PD), clinical attachment level (CAL), gingival marginal level (GML), and radiographic parameters—crestal bone resorption and bone fill was measured at baseline, 3 and 9 months. Results: Over a period of 9 months, a significant reduction was observed in GI 0.88 ± 0.06 (P < 0.001)along with a greater reduction in PD(4.30 ± 1.38 mm), greater gain in CAL (4.35 ± 1.53 mm) as well as a greater bone fill (2.40 ± 0.99 mm) present with Site A (DFDBA+PRF) as compared to Site B (PRF alone). However, slight gingival recession and crestal bone resorption were observed with both groups which were not clinically significant but were statistically significant. Conclusion: The combination of PRF and DFDBA both clinically and radiographically showed much better results as compared to PRF alone in the treatment of periodontal 3 wall intrabony defects over a period of 9 months after surgical intervention.