Relationship between Type 2 diabetes mellitus and aggressiveness of melanoma

Type 2 diabetes mellitus (T2DM) has become increasingly common, and studies have suggested a relationship between T2DM and melanoma. Recently, the presence of T2DM was reportedly associated with more aggressive cutaneous melanoma at diagnosis, based on a large series of cross-sectional multi-centric studies involving 443 patients [1]. In this study, we investigated the relationship between T2DM and melanoma using a mouse tumor model and patient data from our institution.