Rationally designed amyloid inhibitors based on amyloid-related structural studies

Amyloid proteins correlate with a series of degenerative diseases. Targeting amyloid aggregation has remained a hot topic in therapeutic studies. Numerous inhibitors have been developed, but very few have been approved for marketing. Meanwhile, the growing knowledge of amyloid structural characteristics provides a basis for the rational design of inhibitors. Here we introduce the high-resolution structural findings of amyloid fibrils in recent years and discuss the reported strategies toward rationally designed inhibitors based on amyloid-related structural studies. High-resolution structure contributes to the understanding of amyloid aggregation and provides the basis for rational design of amyloid inhibitor. This article reviewed recent structural studies of amyloids and discussed rationally designed inhibitors according to amyloid-related structural studies.