败血症
光热治疗
纳米团簇
内生
硒
生物相容性
体内
合理设计
铜
化学
纳米颗粒
纳米技术
材料科学
医学
免疫学
生物化学
生物
生物技术
有机化学
作者
Yin Gao,Zekun Wang,Yuqing Li,Jie Yang,Ziyu Liao,Jing Liu,Feng Guo,En-hui Yang,Weiyun Wang,Dongdong Sun
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:10 (12): 3137-3157
被引量:6
摘要
The treatment of sepsis caused by bacterial infections is still a huge clinical challenge. As sepsis causes high levels of endogenous H2S in vivo, researchers can design nanomedicines to treat sepsis by in situ sulfurization. Here, we designed and synthesized Cu2O-coated non-metallic core-shell selenium nanoparticles. To cure mice sepsis by ROS burst. Our experimental data displayed that the photothermal effect of Se@Cu9S8 produced by the reaction of Se@Cu2O and endogenous H2S is synergistically antibacterial, and Se@Cu2O has the characteristics of low side effects and high biocompatibility. In summary, our research results verified our design, that copper-selenium nanoclusters may be an efficient strategy to cure sepsis by in situ sulfurization of endogenous H2S, triggering ROS eruptions and photothermal therapy.
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