海马体
氧化应激
小脑
脂质过氧化
DNA损伤
氧化磷酸化
线粒体
乙醇
化学
线粒体DNA
细胞凋亡
核DNA
生物化学
内科学
生物
DNA
内分泌学
医学
基因
作者
Marcella Renis,Vittorio Calabrese,Alessandra Russo,Agata Calderone,Maria Luisa Barcellona,V. Rizza
出处
期刊:FEBS Letters
[Wiley]
日期:1996-07-22
卷期号:390 (2): 153-156
被引量:87
标识
DOI:10.1016/0014-5793(96)00647-3
摘要
Free radical-mediated oxidative damage has been implicated in the pathophysiological mechanisms of apoptosis. In this study we report that statistically significant strand breaks were induced primarily in the hippocampus and cerebellum during chronic, and not acute, ethanol treatment. Damage to DNA observed in hippocampus and cerebellum was also correlated with significant modification in the activities of mitochondrial respiratory complexes I and IV and with a significant increase in lipid peroxidation products. This finding lends support to the fact that hippocampus and cerebellum are brain areas particularly vulnerable to redox changes induced by alcohol intoxication, suggesting lower threshold levels of ethanol tolerance.
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