About 97% of healthy full term infants have bilirubin values of more than 2 mg% during the first week of life, 65% are clinically jaundiced and this is termed physiological jaundice. However, jaundice in the newborn might signal a serious, potentially treatable illness and may cause neurological damage, if the bilirubin level is very much elevated. This study was conducted to determine the incidence of Neonatal hyperbilirubinemia in Shadan Institute of Medical Sciences & to know the underlying aetiology, so that proper management of Hyperbilirubinemia in the newborn can be done. Keywords: Neonatal Hyperbilirubinemia, Serum Bilirubin, Jaundice, Kernicterus