线粒体
细胞生物学
氧化磷酸化
胞浆
癌细胞
生物能学
程序性细胞死亡
细胞凋亡
合成代谢
信号转导
癌症
糖酵解
生物
新陈代谢
生物化学
酶
遗传学
作者
Simone Fulda,Lorenzo Galluzzi,Guido Kroemer
摘要
Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of lethal signal transduction pathways converge on mitochondria to cause the permeabilization of the mitochondrial outer membrane, leading to the cytosolic release of pro-apoptotic proteins and to the impairment of the bioenergetic functions of mitochondria. The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions. Activation of the cell death machinery in cancer cells by inhibiting tumour-specific alterations of the mitochondrial metabolism or by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.
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