Livedoid vasculopathy: an intringuing cutaneous disease * Vasculopatia livedoide: uma doença cutânea intrigante

7 Abstract: Livedoid vasculopathy is a skin disease that occludes the blood vessels of the dermis. It has a pauciinflammatory or non-inflammatory nature. It is characterized by the presence of macular or papu- lar, erythematous-purpuric lesions affecting the legs, especially the ankles and feet, and producing intensely painful ulcerations, which cause white atrophic scars called atrophie blanche. This review includes studies and case reports found in the medical literature regarding the etiopathogenic associa- tions of the disease, particularly those related to thrombophilia, their histopathological findings and the therapeutic approaches used in the difficult clinical management of these cases. Keywords: Leg ulcer; Livedo reticularis; Thrombophilia; Thrombosis; Venous thrombosis Resumo: A vasculopatia livedoide e uma afeccao cutânea oclusiva dos vasos sanguineos da derme, de carater pauci-inflamatorio ou nao-inflamatorio. Caracteriza-se pela presenca de lesoes maculosas ou papulosas, eritemato-purpuricas, nas pernas, especialmente nos tornozelos e pes, as quais produzem ulceracoes intensamente dolorosas, que originam cicatrizes atroficas esbranquicadas, denominadas atrofia branca. Nesta revisao, abordamos os estudos e relatos de caso da literatura medica referentes as associacoes etiopatogenicas da doenca, particularmente as que se referem aos estados de trombofil- ia, seus achados histopatologicos e abordagens terapeuticas empregadas na dificil conducao clinica destes casos. Palavras-chave: Livedo reticular; Trombofilia; Trombose; Trombose venosa; Ulcera da perna