细胞凋亡
发病机制
PI3K/AKT/mTOR通路
机制(生物学)
蛋白激酶B
炎症
癌症
癌症研究
生物信息学
医学
人类健康
生物
免疫学
生物化学
遗传学
环境卫生
哲学
认识论
作者
Fu Jia,Yan Zhang,Yichen Hu,Gang Zhao,Yong Tang,Liang Zou
出处
期刊:Food Chemistry
[Elsevier]
日期:2020-09-01
卷期号:325: 126761-126761
被引量:42
标识
DOI:10.1016/j.foodchem.2020.126761
摘要
Coarse cereals (CC) refer to cereal grains except for rice and wheat which are highly-valued as functional foods with nutritional and pharmacological properties. Owing to their diverse positive effect on chronic diseases, coarse cereals exert a vital role in food industry. CC and the main contents prevent tumor pathogenesis through promoting apoptosis, inducing cell cycle arrest as well as modulating metastasis initiation. Meanwhile, CC ameliorates cardiovascular diseases through affecting multiple pathways, such as CaMKII/p-BFAF-3, NF-κB, MAPK, PI3K/Akt, etc. Besides, CC and the main contents have potential as prebiotics which facilitating the activities and growth of probiotics such as Bifidobacteria and Lactobacillus. However, there’s a lack of report on CC’ beneficial properties and the underlying mechanisms are not fully understood. Here this article explains in detail, the effect and mechanism of CC on chronic diseases like tumor, inflammation and cardiovascular diseases.
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