细胞周期蛋白依赖激酶
生物
细胞周期蛋白
细胞生物学
细胞周期蛋白A2
细胞周期蛋白D
SR蛋白
细胞周期蛋白
RNA剪接
E2F型
周期素
细胞周期
选择性拼接
Polo样激酶
细胞周期蛋白依赖激酶复合物
癌症研究
遗传学
基因
核糖核酸
信使核糖核酸
作者
Pascal Loyer,Janeen H. Trembley
标识
DOI:10.1016/j.semcdb.2020.04.016
摘要
Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin complexes recently identified, as well as “canonical” CDK/Cyclin complexes regulating cell cycle, are implicated in the regulation of gene expression via the phosphorylation of key components of the transcription and pre-mRNA processing machineries. In this review, we summarize the role of CDK/cyclin-dependent phosphorylation in the regulation of transcription and RNA splicing and highlight recent findings that indicate the involvement of CDK11/cyclin L complexes at the cross-roads of cell cycle, transcription and RNA splicing. Finally, we discuss the potential of CDK11 and Cyclins L as therapeutic targets in cancer.
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