翻译后修饰
乙酰化
化学
糖基化
蛋白质组学
蛋白质组
计算生物学
硫酸化
磷酸化
糖基化
生物化学
生物
基因
受体
酶
作者
Luisa Pieroni,Federica Iavarone,Alessandra Olianas,Viviana Greco,Claudia Desiderio,Claudia Martelli,Barbara Manconi,Maria Cristina Sanna,Irene Messana,Massimo Castagnola,Tiziana Cabras
标识
DOI:10.1002/jssc.201900804
摘要
More than 300 different protein post-translational modifications are currently known, but only a few have been extensively investigated because modified proteoforms are commonly present in sub-stoichiometry amount. For this reason, improvement of specific enrichment techniques is particularly useful for the proteomic characterization of post-translationally modified proteins. Enrichment proteomic strategies could help the researcher in the challenging issue to decipher the complex molecular cross-talk existing between the different factors influencing the cellular pathways. In this review the state of art of the platforms applied for the enrichment of specific and most common post-translational modifications, such as glycosylation and glycation, phosphorylation, sulfation, redox modifications (i.e. sulfydration and nitrosylation), methylation, acetylation, and ubiquitinylation, are described. Enrichments strategies applied to characterize less studied post-translational modifications are also briefly discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI