间充质干细胞
脐带
帘布衬里
分子医学
癌基因
细胞周期
干细胞
生物
细胞生物学
细胞
癌症研究
免疫学
成体干细胞
细胞分化
遗传学
基因
作者
Yong Zhuang,Dong Liu,Jinqiu Fu,Qing Shi,Yuanyuan Lu,Xiuli Ju
出处
期刊:Molecular Medicine Reports
[Spandidos Publications]
日期:2014-10-23
卷期号:11 (1): 166-174
被引量:51
标识
DOI:10.3892/mmr.2014.2755
摘要
Mesenchymal stem cells (MSCs) are a potential source of adult stem cells for cell-based therapeutics due to their substantial multilineage differentiation capacity and secretory functions. No information is presently available regarding the maintenance of immunosuppressive properties of this cell type with repeated passages. It was therefore the aim of the present study to analyze the biological properties, particularly the immunoregulatory effect, of MSCs from late passages. The differences between young and old MSCs in morphology, cell surface antigen phenotype, proliferation, gene expression and immunomodulatory ability were investigated. The results of the current study demonstrated that with the passage of cells, senescent MSCs displayed a characteristically enlarged and flattened morphology, different gene expression profiles and stronger immunosuppressive activities. Increased interleukin-6 production may be a possible underlying mechanism for this enhanced immunomodulatory ability of MSCs. These findings suggest that aged MSCs may provide a treatment option for patients with graft versus host disease and other diseases associated with dysregulation of the immune system.
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