生物
转录因子
DNA结合蛋白
DNA
发起人
共识序列
基因
肽序列
遗传学
分子生物学
识别序列
抄写(语言学)
生物化学
基因表达
语言学
限制性酶
哲学
作者
Tsonwin Hai,Fang Liu,Elizabeth A. Allegretto,Michael Karin,M. R. Green
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:1988-10-01
卷期号:2 (10): 1216-1226
被引量:254
标识
DOI:10.1101/gad.2.10.1216
摘要
ATF is a cellular transcription factor involved in the regulation of multiple adenovirus E1A- and cellular cAMP-inducible promoters. Using DNA affinity chromatography, we have purified ATF and found that a series of polypeptides copurify in a sequence-specific manner. We demonstrate that these polypeptides represent a family of proteins that are related by DNA-binding specificity and by immunological cross-reactivity. This family includes the transcription factor AP-1, whose recognition sequence, GTGAGTCAA, differs from the ATF consensus, GTGACGTCAA, by the absence of a cytosine residue. Our results further indicate that there are multiple forms of both ATF and AP-1. The immunological cross-reactivity and related DNA-binding specificities suggest that ATF and AP-1 contain similar amino acid sequences and may have originated from a common gene.
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