Recurrent loss of the Y chromosome and homozygous deletions within the pseudoautosomal region 1: association with male predominance in mantle cell lymphoma

Mantle cell lymphoma (MCL) is a B-cell lymphoproliferative disorder which predominantly affects men. In a large retrospective survey of the European MCL Network including 304 patients, median age was 63 years at first diagnosis with a male preponderance of 76%.[1][1] The genetic hallmark of MCL is