乙酰化
组蛋白乙酰转移酶
生物
组蛋白
SAP30型
HDAC4型
生物化学
组蛋白甲基转移酶
赖氨酸
基因表达
基因
基因表达调控
表观遗传学
氨基酸
作者
Yuan Shen,Wei Wei,Dao‐Xiu Zhou
标识
DOI:10.1016/j.tplants.2015.07.005
摘要
Histone lysine acetylation is well known for being important in the epigenetic regulation of gene expression in eukaryotic cells. Recent studies have uncovered a plethora of acetylated proteins involved in important metabolic pathways, such as photosynthesis and respiration in plants. Enzymes involved in histone acetylation and deacetylation are being identified as regulators of acetylation of metabolic enzymes. Importantly, key metabolites, such as acetyl-CoA and NAD(+), are involved in protein acetylation and deacetylation processes, and their cellular levels may regulate the activity of histone acetyltransferases (HAT) and deacetylases (HDAC). Further research is required to determine whether and how HATs and HDACs sense cellular metabolite signals to control gene expression and metabolic enzyme activity through lysine acetylation and deacetylation.
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