神经科学
新皮层
海马结构
海马体
神经元
疾病
心理学
阿尔茨海默病
神经退行性变
生物
医学
病理
作者
John H. Morrison,Patrick R. Hof
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1997-10-17
卷期号:278 (5337): 412-419
被引量:1244
标识
DOI:10.1126/science.278.5337.412
摘要
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.
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