陶氏病
神经退行性变
失智症
神经科学
帕金森病
τ蛋白
Tau病理学
医学
痴呆
病理
机制(生物学)
皮质基底变性
疾病
进行性核上麻痹
生物
阿尔茨海默病
哲学
认识论
作者
Maria Grazia Spillantini,Michel Goedert
标识
DOI:10.1016/s1474-4422(13)70090-5
摘要
The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many human neurodegenerative diseases, collectively referred to as tauopathies. Dominantly inherited mutations in MAPT, the gene that encodes tau, cause forms of frontotemporal dementia and parkinsonism, proving that dysfunction of tau is sufficient to cause neurodegeneration and dementia. However, most cases of tauopathy are not inherited in a dominant manner. The first tau aggregates form in a few nerve cells in discrete brain areas. These become self propagating and spread to distant brain regions in a prion-like manner. The prevention of tau aggregation and propagation is the focus of attempts to develop mechanism-based treatments for tauopathies.
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