医学
免疫系统
酒精性肝病
敏化
免疫学
细胞因子
免疫抑制
肝病
疾病
内科学
肝硬化
作者
Shirish Barve,Swati Joshi‐Barve,Zhenyuan Song,Daniell B. Hill,Prachi Hote,Ion V. Deaciuc,Craig J. McClain
标识
DOI:10.1111/j.1440-1746.2006.04590.x
摘要
Alcoholic liver disease (ALD) remains a leading cause of death in the USA. Defining mechanisms for liver cell death in ALD in order to develop potential new agents for therapeutic intervention is a major focus of the authors' work. Abnormal cytokine metabolism is a major feature of ALD, and a thorough understanding of both mechanisms and interactions of cytokine overproduction and sensitization are critical to developing a possible treatment for ALD. S-Adenosylmethionine has been used in a variety of animal studies and clinical trials and has been reported to improve biochemical parameters of liver function. Last, immunosuppression associated with chronic alcohol abuse is an important predisposing factor to opportunistic infections and cancer. It is the authors' working hypothesis that alcohol consumption leads to chronic activation of the immune system.
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