S22 * LIVER TRANSPLANTATION: A EUROPEAN PERSPECTIVE SYMPOSIUM OF THE EUROPEAN FEDERATION OF ADDICTION SOCIETES (EUFAS) II

Results.Between 2007-2012, 252 alcohol-exposed and 274 unexposed women were enrolled.After adjustment for covariates, alcohol dose was associated with significantly lower concentrations of Cu, folate and vitamin D; alcohol dose was associated with significantly higher levels of homocysteine (p's <0.05).Among 298 children who completed the Bayley, those in the alcohol-exposed group scored ~10 points lower on the Mental (MDI) and Motor (PDI) Development Indices than unexposed infants ( p's <0.001).There was a significant interaction between alcohol group and the vitamin intervention; those in the alcohol exposed/intervention group scored approximately 11 points higher on the MDI ( p < 0.001) and 6 points higher on the PDI ( p <0.04) than those assigned to standard of care.Conclusion.These data suggest that maternal nutritional status is associated with alcohol dose in pregnancy and that a vitamin supplement intervention in pregnancy may have a beneficial effect.S21.3