Research progress in heparanase promoting tumor metastasis

Heparanase is the only mammalian heparan sulfate-degrading enzymes;it could cleave heparan sulfate(HS) which links to heparan sulfate Proteoglycans(HSPGs).In this review,the heparanase's effects on tumor angiogenesis,its expression in normal tissue,tumor tissue and metastatic tissue,and its correlation to tumor metastasis were described;recent progress in searching for novel antitumor drugs through screening for inhibitor of heparanase was summarized.