Objective To discuss the effect of fractures of the long tube bone treated with interlocking intramedullary nail.Methods Retrospective review of 112 patients with long tube bone fractures treated with interlocking intramedullary nail.Results Patients were followed-up for an average of 14 months,all fractures healed.Evaluated the effect according to the criteria of Johner and Wruh 88 cases excellent,20 cases good.Conclusion Interlocking intramedullary nail is a good internal fixation for treatment of fractures of the long tube bone as long as appropriate indication is selected.