Synergic Effect of Se and Co on the Electrophysiological Properties of Myocardial Cells of the rat

Objective:To explore the synergic effect of Se and Co on the electrophysiological properties of myocardial cells. Methods: Intracellular microelectrode technique was used to study the electrophysiological changes of the myocardial cells cultured at the state of the different Se and Co concentration. Results: It has been confirmed that Co lowered the RP ? APA and shorted the APD 50 of the cultured cell. However, when Se was added to the experimental system, these electrophysiological parameters have no significantly changes than the control. Conclusions: It suggested that Co injury the cultured myocardial cells, and Se prevent these cells from the injury.