乙型肝炎表面抗原
肝细胞癌
免疫组织化学
DNA
原位杂交
病变
乙型肝炎病毒
生物
病毒学
病理
癌症研究
分子生物学
医学
病毒
信使核糖核酸
基因
遗传学
生物化学
作者
Ji Zhou,Yaojie Liang,Daxiong Feng
出处
期刊:PubMed
日期:1995-02-01
卷期号:24 (1): 18-20
摘要
40 cases of hepatocellular carcinoma (HCC) and their surrounding tissues were studied on paraffin-embedded sections by in situ hybridization and immunohistochemical double labelling techniques. The positive rates of HBV DNA and HBsAg were 65% and 82.5% respectively, suggesting that HBV infection is a significant cause of HCC. HBV DNA and HBsAg signals in the pericarcinomatous tissues were stronger than that in cancer cells. Reduced replication caused by integration of HBV DNA in HCC may explain this phenomenon. We found that the small "piece-meal like" inclusions which existed only in HCC may be a special cancer related pattern of HBsAg. There were stronger signals of HBsAg in the small cell LCD than in other pericarcinomatous lesions, supporting the theory that the small cell LCD is more likely to be a precarcinomatous lesion.
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