The Maillard reaction of liquid milk has significant consequences for the product quality during the shelf-life storage. A detailed kinetic study of hydroxymethylfurfural( B-HMF) was performed by liquid milk which was stored at 4℃,25℃ and 37℃ up to 5 months. Pure milk( Gabriel package and Tetra Pak two kinds) and lowlactose milk were used in the study. The results showed that the rate of combined HMF formation followed zero order kinetic overall. The kinetic model B-HMF's formation predition was established.