Hypothalamic Lipid Nutritional Sensing and Mechanisms in Appetite Regulation

The formation of appetite is closely related to the health of the body,and is controlled by nutritional signal,ROS and a series of hormone signals.Hypothalamus is the main central to integrate all sorts of appetite signals.The current researches indicated that lipids were detected by specialized fuel-sensing neurons.The fatty acids and their intracellular metabolites were both involved in the body's energy homeostasis regulation,either by the non-metabolic dependent or by metabolic dependent way,thus played important roles in appetite regulation and energy homeostasis.This paper reviewed the lipid nutritional sensing and the appetite regulation mechanism in the hypothalamus.