Toxic baits of 402 chemicals were evaluated in the laboratory to determine their effectiveness in controlling the red imported fire ant, Solenopsis invicta Buren. No chemical bait was as consistently as effective as mirex for the control of the red imported fire ant, although compounds ENT-27931, ENT-27932, ENT-27933, ENT-27934, ENT-27935, ENT-27936, ENT-27937, and ENT-62469 were promising and exhibited relatively consistent delayed action over a 10 to 99-fold dosage.