氰化
化学
自由基环化
催化作用
键裂
激进的
自由基引发剂
自由基反应
铜
药物化学
光化学
自由基离子
有机化学
聚合
离子
聚合物
作者
Yihang Jiao,Mong‐Feng Chiou,Yajun Li,Hongli Bao
标识
DOI:10.1021/acscatal.9b01060
摘要
A copper-catalyzed radical acyl-cyanation of alkenes with aldehydes, employing TBHP as an initiator, has been developed and is reported in this study. Mechanistic studies support the radical pathway of the reaction, which starts from a tert-butoxy radical. Theoretical studies with DFT calculations and our experimental results suggest that metal species is the dominant factor for the β-Me scission of Ot-Bu radical rather than temperature, and the β-Me scission of a free Ot-Bu radical is concentration-dependent kinetically unfavorable in the presence of aldehydes in this reaction.
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