Stroke mimics are common differential diagnoses of stroke. This article describes common stroke mimics and their presentations. It provides nurses with an overview of how to distinguish stroke mimics from a stroke, and practical information on triaging and diagnosing stroke and stroke mimics in the clinical setting. Stroke and stroke mimics have several similarities and several important differences. A comprehensive patient history, clinical examination, use of assessment tools and the results of medical imaging can guide nurses to differentiate stroke from a stroke mimic.