医学
危险系数
入射(几何)
置信区间
套式病例对照研究
冲程(发动机)
内科学
回顾性队列研究
一氧化碳中毒
病例对照研究
优势比
比例危险模型
毒物控制
急诊医学
工程类
物理
光学
机械工程
作者
Kyeongmin Kwak,Min Kim,Won-Jun Choi,Young‐Su Ju,Jong-Tae Park
标识
DOI:10.1016/j.jstrokecerebrovasdis.2020.105496
摘要
Objectives Severe neurological sequelae occur in patients with carbon monoxide (CO) intoxication; however, whether the latter increases the long-term risk of developing ischemic stroke is unclear. We investigated the association between CO intoxication and ischemic stroke using data from the Korean National Health Information Database. Materials and Methods We performed a retrospective, nested case-control study of 27,984 individuals treated for CO intoxication and 27,984 sex- and age-matched controls. Initially, we calculated the overall incidence and hazard ratio (HR) of ischemic stroke using conditional logistic regression. Thereafter, we calculated the incidences and HRs according to covariates and follow-up periods. Results The CO intoxication group had a significantly higher risk of developing ischemic stroke than the control group (adjusted HR 2.31, 95% CI [confidence interval] = 2.01–2.65). Male sex (adjusted HR 2.73, 95% CI = 2.23-3.34), age <40 (adjusted HR 3.53, 95% CI = 2.15-5.82), low income (adjusted HR 2.55, 95% CI = 1.56–4.15), comorbidities (adjusted HR 2.59, 95% CI = 1.48–4.52), and current smokers (adjusted HR 3.55, 95% CI = 1.67–7.60) had a higher risk of ischemic stroke. The risk of ischemic stroke was highest within 2 years after CO intoxication (adjusted HR 7.47, 95% CI = 2.76–20.26), and even >6 years after, the risk remained significantly higher than in the control group (adjusted HR 1.84, 95% CI = 1.53–2.20). Conclusions CO intoxication and the long-term risk of ischemic stroke are associated.
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