医学
二甲双胍
四分位间距
内科学
肾脏疾病
乳酸性酸中毒
2型糖尿病
糖尿病
回顾性队列研究
队列
肾功能
酸中毒
重症监护医学
危险系数
内分泌学
胰岛素
置信区间
作者
Benjamin Lazarus,Aozhou Wu,Jung‐Im Shin,Yingying Sang,G. Caleb Alexander,Alex Secora,Lesley A. Inker,Josef Coresh,Alex R. Chang,Morgan E. Grams
标识
DOI：10.1001/jamainternmed.2018.0292
摘要
Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin. This may reflect uncertainty regarding the risk of acidosis in patients with chronic kidney disease.
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